Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

Harry W. Kestier, D J Ringler, Kazuyasu Mori et al. · Cell · 1991 · 1.6K citations

Viral Replication, Molecular Virology, Medicine +11

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

Nicholas J. Deacon, Anna Tsykin, A. Solomon et al. · Science · 1995 · 1.2K citations

Genetics, Immunology, Pathology +17

Chronic Arthritis in Goats Caused by a Retrovirus

Timothy B. Crawford, Daniel Adams, William P. Cheevers et al. · Science · 1980 · 387 citations

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

Romas Geleziunas, Weiduan Xu, Kohsuke Takeda et al. · Nature · 2001 · 320 citations

Medicine, Human Retrovirus, Immunology +12

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway

Anastassia D. Blagoveshchenskaya, Laurel Thomas, Sylvain Féliciangéli et al. · Cell · 2002 · 301 citations · Full text

Medicine, Human Retrovirus, Immunology +6