Thereapeutic response of <i>Tribulus terrestris</i> (gokhru) aqueous extract on hyperoxaluria in male adult rats

Abstract

Abstract The effect of an aqueous extract of Tribulus terrestris (an indigenous drug) administered orally at a dose of 5 g/kg body weight was studied in six male adult rats in whom hyperoxaluria was induced and maintained by hydroxyproline and sodium glycolate respectively. Twenty‐four hour urinary oxalate excretion reversed to normal, from 1.97±0.314 to 0.144±0.004 mg/mg creatinine ( p &lt;0.01) within 21 days of administration of T. terrestris extract and remained so until 15 days after withdrawal of extract and sodium glycolate.