Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.3K citations

Natural Sciences, Rna Splicing, Rna Biology +9

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

Stephen M. Keyse, Rex M. Tyrrell · Proceedings of the National Academy of Sciences · 1989 · 1.3K citations · Full text

Biochemistry, Heme Homeostasis, Natural Sciences +15

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Jawed Alam, Daniel P. Stewart, Cheri Touchard et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

Biliverdin reductase: A major physiologic cytoprotectant

David E. Barañano, Mahil Rao, Christopher D. Ferris et al. · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

Brent W. Zanke, Kimberly Boudreau, Elizabeth A. Rubie et al. · Current Biology · 1996 · 452 citations · Full text

Reductive Stress, Signal Transduction, Cell Regulation +12