Arginine or Nitrate Enhances Antibiotic Susceptibility of <i>Pseudomonas aeruginosa</i> in Biofilms

Abstract

Arginine enhanced the killing of Pseudomonas aeruginosa by ciprofloxacin and tobramycin under anaerobic, but not aerobic, growth conditions. Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone.