Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile α,β-Unsaturated Amino Ketones

Abstract

Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.