Concepedia

Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile α,β-Unsaturated Amino Ketones

Andrejs Pelšs, Esa T. T. Kumpulainen, Ari M. P. Koskinen

The Journal of Organic Chemistry · 2009 · 43 citations · 27 references

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Concepts

Abstract

Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.

References

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