Capnellenes from the Formosan Soft Coral <i>Capnella imbricata</i>

Abstract

Three anti-inflammatory sesquiterpenes, Delta (9(12))-capnellene-8beta,10alpha-diol ( 1), 8alpha-acetoxy-Delta (9(12))-capnellene-10alpha-ol ( 2), and Delta (9(12))-capnellene-10alpha-ol-8-one ( 3), five new sesquiterpenes, Delta (9(12))-capnellene-8beta,15-diol ( 4), Delta (9(12))-capnellene-8beta,10alpha,13-triol ( 5), Delta (9(10))-capnellene-12-ol-8-one ( 6), 8beta,10alpha-diacetoxy-Delta (9(12))-capnellene ( 7), and 8beta-acetoxy-Delta (9(12))-capnellene ( 8), and a known sesquiterpene, Delta (9(12))-capnellene-8beta-ol ( 9), were isolated from the acetone/methylene chloride extracts of the Formosan soft coral Capnella imbricata. The structures of these compounds were elucidated by extensive spectroscopic analysis.