Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

Heiko Leutbecher, Szilvia Hajdok, Christina Braunberger, Melanie Neumann, Sabine Mika, Jürgen Conrad

Green Chemistry · 2009 · 59 citations · 32 references

Concepts

Abstract

The enzymes tyrosinase and laccase from a crude extract of the button mushroom (Agaricus bisporus) can be employed to catalyze the domino reaction between phenol and various cyclic 1,3-dicarbonyls using atmospheric oxygen as the oxidizing agent and yielding annulated benzofuranes in a highly efficient and sustainable manner.

References

32