Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

Shioko Kimura, Yasumasa Hara, Thierry Pineau et al. · Genes & Development · 1996 · 1.2K citations · Full text

Genetics, Organ Development, T/ebp Null Mouse +19

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

Domenico Lazzaro, Melanie Price, Mario De Felice et al. · Development · 1991 · 897 citations

Brain Development, Genetics, Adult Thyroid +17

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

Stefania Guazzi, Melanie Price, Mario De Felice et al. · The EMBO Journal · 1990 · 540 citations · Full text

Chromatin, Transcriptional Regulation, Natural Sciences +8

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.

Robert J. Bohinski, Roberto Di Lauro, Jeffrey A. Whitsett · Molecular and Cellular Biology · 1994 · 522 citations · Full text

Chromatin, Transcriptional Regulation, Genetics +14

PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis

Paolo Emidio Macchia, Paola Lapi, Heiko Krude et al. · Nature Genetics · 1998 · 502 citations

Developmental Biology, Genetic Disorder, Genetics +6