Renal angiomyolipoma. A clinicopathologic study of 32 cases

Abstract

The data from 32 cases of angiomyolipoma (renal hamartoma) are presented: 23 of the tumors were removed at surgery and nine at autopsy. The histopathologic findings are reviewed and the spectrum of gross renal involvement is emphasized. On the basis of the duration of symptoms and findings and the subsequent course of patients subjected to surgical resection, the clinical behavior of the tumor is assessed. Of particular interest is the relationship of this tumor to the tuberous sclerosis complex. Data presented indicate that many of the patients have various components of the syndrome, which in some patients have familial manifestations. It is inferred from this study that the tuberous sclerosis complex may vary in expression from a solitary renal tumor to the fully developed clinical syndrome.