U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

John David Dignam, Russell M. Lebovitz, R G Roeder · Nucleic Acids Research · 1983 · 11.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Efficient<i>in vitro</i>synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

Douglas A. Melton, Paul A. Krieg, Michael R. Rebagliati et al. · Nucleic Acids Research · 1984 · 6.4K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +11

Are snRNPs involved in splicing?

Michael R. Lerner, John A. Boyle, Stephen M. Mount et al. · Nature · 1980 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +10

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

Michael R. Lerner, Joan A. Steitz · Proceedings of the National Academy of Sciences · 1979 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

Stephen M. Mount, Ingvar Pettersson, M. Hinterberger et al. · Cell · 1983 · 586 citations · Full text

Life Sciences, Genetics, Molecular Biology +14