Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

Jürgen M. Lehmann, James M. Lenhard, Beverly B. Oliver et al. · Journal of Biological Chemistry · 1997 · 1.1K citations · Full text

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

Jang Hyun Choi, Alexander S. Banks, Jennifer L. Estall et al. · Nature · 2010 · 877 citations

Obesity, Metabolic Syndrome, Molecular Pharmacology +8

RM1: A reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I

Gerd B. Rocha, Ricardo O. Freire, Alfredo M. Simas et al. · Journal of Computational Chemistry · 2006 · 673 citations

Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search

Ajay N. Jain · Journal of Computer-Aided Molecular Design · 2007 · 581 citations

Engineering, Medicine, Surflex-dock 2.1 +11

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Jang Hyun Choi, Alexander S. Banks, Theodore M. Kamenecka et al. · Nature · 2011 · 532 citations · Full text

Molecular Pharmacology, Diabetes Management, Signal Transduction +8