Mechanistic Basis for Type 2 Long QT Syndrome Caused by KCNH2 Mutations that Disrupt Conserved Arginine Residues in the Voltage Sensor

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Medicine, Genetics, Molecular Genetics +13

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

Michael C. Sanguinetti, Nancy K. Jurkiewicz · The Journal of General Physiology · 1990 · 1.5K citations · Full text

Medicine, Cardiology, Pharmacology +17

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

Matthew C. Trudeau, Jeffrey W. Warmke, Barry Ganetzky et al. · Science · 1995 · 1.2K citations

Natural Sciences, Genetics, Molecular Genetics +17

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Tom O’Hara, László Virág, András Varró et al. · PLoS Computational Biology · 2011 · 1.2K citations · Full text

Medicine, Cardiology, Physiology +17