Investigative Ophthalmology & Visual Science · 2009 · 64 citations · 23 references
Fetal-derived hRPCs show molecular characteristics indicative of a retinal progenitor state up to P6 (latest passage studied). They show a progressive decrease in the expression of immature markers as they reach P6. These cells are functional, respond to excitatory neurotransmitters, and exhibit changes in expression patterns in response to co-culture with mouse retina.
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<i>Pax-6</i>, a murine paired box gene, is expressed in the developing CNS
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Retinal repair by transplantation of photoreceptor precursors
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Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
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The role of <i>Pax-6</i> in eye and nasal development
Justin C. Grindley, Duncan Davidson, Robert E. Hill · Development · 1995 · 671 citations