Concepedia

Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy

Leyi Gu, Yan Dai, Jin Xu, Sandeep K. Mallipattu, Lewis Kaufman, Paul E. Klotman, John Cijiang He, Peter Y. Chuang

AIDS · 2013 · 50 citations · 24 references

DOIFull text

Open access

Abstract

Development of glomerular as well as tubulointerstitial injuries in the Tg26 HIVAN model is dependent on podocyte STAT3 expression. Inhibition of STAT3 could be a potential adjunctive therapy for the treatment of HIVAN.

References

24

Guidelines for the Management of Chronic Kidney Disease in HIV-Infected Patients: Recommendations of the HIV Medicine Association of the Infectious Diseases Society of America

Samir K. Gupta, Joseph A. Eustace, Jonathan Winston et al. · Clinical Infectious Diseases · 2005 · 583 citations · Full text

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

Markus Gödel, Björn Hartleben, Nadja Herbach et al. · Journal of Clinical Investigation · 2011 · 533 citations

, , +21

A New Method for Large Scale Isolation of Kidney Glomeruli from Mice

Minoru Takemoto, Noomi Asker, Holger Gerhardt et al. · American Journal Of Pathology · 2002 · 514 citations · Full text

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Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

Jörg J. Jacoby, April Kalinowski, Mu-Gen Liu et al. · Proceedings of the National Academy of Sciences · 2003 · 349 citations · Full text

Podocyte‐specific expression of cre recombinase in transgenic mice

Marcus J. Moeller, Silja K. Sanden, Abdulsalam Soofi et al. · genesis · 2002 · 320 citations