Palladium-Catalyzed Benzylation of Carboxylic Acids with Toluene via Benzylic C–H Activation

Abstract

Direct benzylation of carboxylic acids with toluene has been developed via palladium-catalyzed C-H acyloxylation under 1 atm of oxygen. This reaction demonstrates good functional group tolerance and high yields, providing a facile, atom-economic, and efficient method for the synthesis of benzyl esters.