Genetics · 2004 · 14 citations · 22 references
MedicineGeneticsMolecular GeneticsEmbryogenesisEpigeneticsGene ExpressionGenomic ImprintingGonadal Sex DifferentiationMaternal Effect GenesSex DeterminationSex DifferentiationSexual DifferentiationEarly Embryo DevelopmentGenetic ImprintingImprinted Gene RegulationMaternal Effect EpigeneticsMolecular Sex DifferentiationSex Determination GenesSex Determining Gene RegulationSex-specific Gene Expression
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.
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Male development of chromosomally female mice transgenic for Sry
Peter Koopman, John Gubbay, Nigel Vivian et al. · Nature · 1991 · 2.2K citations
Dnmt3L and the Establishment of Maternal Genomic Imprints
Déborah Bourc’his, Guoliang Xu, Chyuan‐Sheng Lin et al. · Science · 2001 · 1.4K citations
A male-specific role for <i>SOX9</i> in vertebrate sex determination
Jill Kent, Susan C. Wheatley, Jane E. Andrews et al. · Development · 1996 · 716 citations