Transdermal Films of Ephedrine

Abstract

AbstractEphedrine, often used in the treatment of asthma, is a good candidate for development of its transdermal therapeutic system. This investigation reports the design of polymeric matrix type transdermal films of ephedrine and its hydrochloride salt. The films possessing appropriate physico-chemical qualities were tested for in vitko and in vivo drug diffusion pattern, stability and skin irritation. The films were found to be free from skin irritation and stable at room temperature but adversely affected by extremes of humidity or high temperature. Both systems gave adequate release of drug and diffusion through skin into systemic circulation when tested on human volunteers.