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Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans

Jan Tack, Ingrid Demedts, Ann Meulemans, J. A. J. Schuurkes, J. Janssens

Gut · 2002 · 211 citations · 37 references

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Abstract

In humans, fasting gastric tone and sensitivity to distension are not influenced by nitric oxide synthase inhibition, but the gastric accommodation reflex involves activation of nitrergic neurones. Inhibition of nitric oxide synthase impairs accommodation and enhances meal induced satiety.

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