Concepedia

Alterations in Metabotropic Glutamate Receptor 1α and Regulator of G Protein Signaling 4 in the Prefrontal Cortex in Schizophrenia

David W. Volk, Stephen M. Eggan, David A. Lewis

American Journal of Psychiatry · 2010 · 109 citations · 39 references

DOIFull text

Open access

Abstract

Together, higher mGluR1α and lower RGS4 mRNA levels may represent a disturbed "molecular hub" in schizophrenia that may disrupt the function of prefrontal cortical networks, including both GABA and glutamate systems.

References

39

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Jo Vandesompele, Katleen De Preter, Filip Pattyn et al. · Genome biology · 2002 · 19.7K citations · Full text

Applied Linear Statistical Models

Eric R. Ziegel, John Neter, William Wasserman et al. · Technometrics · 1992 · 10K citations

, , +3

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

Leisa A. Glantz, David A. Lewis · Archives of General Psychiatry · 2000 · 1.6K citations

A second endogenous cannabinoid that modulates long-term potentiation

Nephi Stella, Paul Schweitzer, Daniele Piomelli · Nature · 1997 · 1.5K citations · Full text

, , +9

Brain monoglyceride lipase participating in endocannabinoid inactivation

T. P. Dinh, D. L. Carpenter, F.M. Leslie et al. · Proceedings of the National Academy of Sciences · 2002 · 1.3K citations · Full text