Annals of the New York Academy of Sciences · 2002 · 13 citations · 6 references
Life SciencesCell BiologyEndocrinologyApoptosisCell SignalingSignal TransductionApoptosis RegulationApoptotic SignalingCaspase ActivationCell DeathSphingolipid MetabolismCaspase SignalingCaspase-mediated ApoptosisCeramide SignalingSphingolipid SignalingSphingomyelin MetabolismSphingosine MetabolismSphingosine-1-phosphate Signaling
It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.
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Sphingosine-induced apoptosis is dependent on lysosomal proteases
Katarina Kågedal, Ming ZHAO, Iréne Svensson et al. · Biochemical Journal · 2001 · 341 citations · Full text
Sphingosine-induced apoptosis is dependent on lysosomal proteases
Katarina Kågedal, Ming ZHAO, Iréne Svensson et al. · Biochemical Journal · 2001 · 268 citations
Maria Grazia Cifone, Graziella Migliorati, Raffaella Parroni et al. · Blood · 1999 · 187 citations