Annals of the New York Academy of Sciences · 2005 · 73 citations · 9 references
Life SciencesImmunologyInternal MedicineAutoimmunityClinical ImmunologyRheumatologyAutoantibodiesAutoimmune Disease DiagnosticsAutoimmune DiseasesAutoimmune Rheumatic DiseasesRheumatoid ArthritisSystemic Lupus ErythematosusAnti-cyclic Citrullinated Peptide AntibodiesAnti-cyclic Citrullinated Peptide Antibody TestingAutoantibodies In Rheumatic DiseaseClinical Utility AnalysisClinical Utility AssessmentMatched Control GroupRheumatoid Arthritis DiagnosticsRheumatoid Factor Testing
Our objective was to determine the frequency of antibodies to cyclic citrullinated peptides (CCPs) in a series of patients with a variety of rheumatic diseases. Seven hundred consecutive serum samples from patients at an outpatient clinic were tested for the presence of rheumatoid factor (RF) and anti-CCP. Clinical diagnosis, radiographic information, and other laboratory data were taken from patients' charts. The sensitivity and specificity of anti-CCP reactivity for the diagnosis of rheumatoid arthritis (RA) were 74.0% and 94.5%, respectively; the corresponding results for RF were 69.7% sensitivity and 81.0% specificity. Highest rates of false-positive RF tests were found in patients with SLE (18.3% vs. 12.7% CCP), Sjögren's syndrome (73.3% vs. 3.3% CCP), and a control group with chronic hepatitis (24.7% vs. 1.3% CCP). The detection of anti-CCP is useful for the diagnosis of RA because of its similar sensitivity but higher specificity compared with RF. Anti-CCP also helps to diagnose other inflammatory and noninflammatory diseases (especially connective tissue diseases) by reducing the rate of false-positive results in comparison with RF.
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Revised Criteria for the Classification of Rheumatoid Arthritis
Frank C. Arnett · Orthopaedic Nursing · 1990 · 7.7K citations