Inhibition of the Cobalt Acetate/Bromide-Catalyzed Hydrogen Peroxide Oxidation of 4-<i>tert</i>-Butyltoluene

Abstract

The hydrogen peroxide oxidation of 4- tert -butyltoluene to 4- tert -butylbenzaldhyde, an important fragrance intermediate, catalyzed by cobalt acetate and bromide in acetic acid was investigated again. The initial stages of the reaction appear to be rapid and quantitative, but after approximately 25−30% conversion, the process ceases. Overoxidation to 4- tert -butylbenzoic acid does not occur. It appears that both water and the aldehyde product itself inhibit further oxidation. An engineering solution to remove the product continuously seems required for process optimization.