The INFUSE-Morphine IIB Study: Use of Recombinant Human Hyaluronidase (rHuPH20) to Enhance the Absorption of Subcutaneous Morphine in Healthy Volunteers

A recombinant human enzyme for enhanced interstitial transport of therapeutics

Louis H. Bookbinder, Anthony Hofer, Michael F. Haller et al. · Journal of Controlled Release · 2006 · 259 citations

Cell-based Drug Delivery, Biochemistry, Medicine +10

The pharmacokinetics of morphine and morphine glucuronide metabolites after subcutaneous bolus injection and subcutaneous infusion of morphine

R. Stuart‐Harris, S. P. Joel, PJ McDonald et al. · British Journal of Clinical Pharmacology · 2000 · 96 citations · Full text

Hypodermoclysis for the administration of fluids and narcotic analgesics in patients with advanced cancer

Éduardo Bruera, Mary Ann Legris, Norma Kuehn et al. · Journal of Pain and Symptom Management · 1990 · 92 citations

Advanced Cancer, Medicine, Pharmacology +8

Hypodermoclysis: an alternative infusion technique.

M Sasson, Pesach Shvartzman · PubMed · 2001 · 92 citations

Electrolyte Disorder, Vascular Surgery, Alternative Infusion Technique +10

A prospective, within-patient, crossover study of continuous intravenous and subcutaneous morphine for chronic cancer pain

Kristine A. Nelson, Paul Glare, Declan Walsh et al. · Journal of Pain and Symptom Management · 1997 · 77 citations

Pain Therapy, Pain Research, Health Sciences +12