Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton et al. · PubMed · 1998 · 4.1K citations

Genetic Testing, Cancer Pathology, Genetics +19

Identification and characterization of the familial adenomatous polyposis coli gene

Joanna Groden, Andrew Thliveris, Wade S. Samowitz et al. · Cell · 1991 · 2.8K citations

Molecular Epidemiology, Genetic Disorder, Medicine +10

APC mutations occur early during colorectal tumorigenesis

Steven M. Powell, Nathan Zilz, Yasmin Beazer-Barclay et al. · Nature · 1992 · 1.9K citations

Somatic Variant, Apc Mutations, Medicine +6

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen, Michael Dodge, Wei‐Jen Tang et al. · Nature Chemical Biology · 2009 · 1.4K citations · Full text

Signal Transduction, Signaling Pathway, Medicine +9

Somatic mutations of the <i>APC</i> gene in colorectal tumors: mutation cluster region in the <i>APC</i> gene

Yasuo Mori, Hiroki Nagse, Hiroshi Ando et al. · Human Molecular Genetics · 1992 · 934 citations · Full text

Mutation Cluster Region, Somatic Variant, Somatic Mutations +12