Concepedia

Urinary Trypsin Inhibitors Afford Cardioprotective Effects through Activation of PI3K-Akt and ERK Signal Transduction and Inhibition of p38 MAPK and JNK

Seok J. Kim, Kyung Yeon Yoo, Cheol Won Jeong, Woong M. Kim, Hyung K. Lee, Hong Beom Bae, Sang Hyun Kwak, Mei Li, Jong‐Un Lee

Cardiology · 2009 · 24 citations · 21 references

DOI

Abstract

UTI has a protective effect against regional myocardial I/R injury through activation of survival kinases PI3K-Akt and ERK1/2 and attenuation of p38 and JNK.

References

21

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Jerry E. Chipuk, Tomomi Kuwana, Lisa Bouchier‐Hayes et al. · Science · 2004 · 2K citations

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Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

Derek J. Hausenloy · Cardiovascular Research · 2002 · 575 citations · Full text

Postconditioning Inhibits Mitochondrial Permeability Transition

Laurent Argaud, Odile Gateau-Roesch, Olivier Raisky et al. · Circulation · 2005 · 542 citations · Full text

Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction

M. P MAXWELL, D HEARSE, Derek M. Yellon · Cardiovascular Research · 1987 · 510 citations · Full text