Concepedia

Diazepam Under Hyperbaric Conditions in Rats

Acta Anaesthesiologica Scandinavica · 1980 · 12 citations · 6 references

Concepts

High Helium PressureHypertensionPharmacotherapyNeuromuscular BlockadeSocial SciencesAnesthesia PracticeNeuropharmacologyNervous SystemPharmacologyHyperbaric ConditionsAnaesthetic AgentNeurophysiologyPhysiologyRighting ReflexDiazepam-treated RatsNeuroscienceAnesthesiaMedicineAnesthesiology

Abstract

The effect of diazepam, expressed as loss of the righting reflex, in 60 adult rats compressed with oxygen/helium to 90 ATA was compared to 18 diazepam-treated rats at 1 ATA. A marked pressure reversal of the loss of righting reflex was found. Convulsions provoked by high helium pressure were prevented by diazepam and the symptoms of High Pressure Nervous Syndrome (HPNS) were reduced.

References

6

The Physiology and Medicine of Diving

J. N. Norman · Occupational and Environmental Medicine · 1983 · 311 citations · Full text

Physiological Principle, Health Sciences, Physiology +9

A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats

A.J. Christmas, Douglas Maxwell · Neuropharmacology · 1970 · 189 citations

Exploratory Behaviour, Behavioral Sciences, Psychoactive Drug +15

Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquillisers

Michael J. Halsey, Bridget Wardley‐Smith · Nature · 1975 · 119 citations

Medicine, Anesthetic Mechanism, Anesthesia Practice +7

PRESSURE REVERSAL OF GENERAL ANAESTHESIA—A MULTI-SITE EXPANSION HYPOTHESIS

Michael J. Halsey, Bridget Wardley‐Smith, C.J. Green · British Journal of Anaesthesia · 1978 · 101 citations

Medicine, Anesthesia Practice, Anesthesia +2

Ketamine/Diazepam Infusion Anaesthesia With Special Attention to the Effect on Cerebrospinal Fluid Pressure and Arterial Blood Pressure

Thor Thorsen, L Gran · Acta Anaesthesiologica Scandinavica · 1980 · 28 citations

Hypertension, Pharmacotherapy, Special Attention +16