Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Neurophysiology, Neuroanatomy, Related Pentapeptides +11

Analgesia from Electrical Stimulation in the Brainstem of the Rat

David J. Mayer, Thomas L. Wolfle, Huda Akil et al. · Science · 1971 · 759 citations

Acute Pain, Pain Medicine, Anesthetic Mechanism +19

On the central sites for the antinociceptive action of morphine and fentanyl

A. Herz, K. Albus, J Metys et al. · Neuropharmacology · 1970 · 267 citations

Health Sciences, Pain Medicine, Medicine +11

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

John Hughes, Terry Smith, Barry A. Morgan et al. · Life Sciences · 1975 · 241 citations

Molecular Pharmacology, Biochemistry, Medicine +8

Opiate receptor in normal and drug altered brain function*

Solomon H. Snyder · Nature · 1975 · 183 citations

Psychoactive Drug, Neurophysiology, Neuroanatomy +8