Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Analgesia from Electrical Stimulation in the Brainstem of the Rat

David J. Mayer, Thomas L. Wolfle, Huda Akil et al. · Science · 1971 · 763 citations

Life Sciences, Neurobiology, Neuroscience +16

On the central sites for the antinociceptive action of morphine and fentanyl

A. Herz, K. Albus, J Metys et al. · Neuropharmacology · 1970 · 268 citations

Medicine, Neuroscience, Pharmacology +13

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

John Hughes, Terry Smith, Barry A. Morgan et al. · Life Sciences · 1975 · 242 citations

Medicine, Biochemistry, Pharmacology +14

Opiate receptor in normal and drug altered brain function*

Solomon H. Snyder · Nature · 1975 · 183 citations

Medicine, Neuroscience, Pharmacology +12