Concepedia

Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

Chiaki Isobe, Takashi Abe, Yasuo Terayama

Neuroscience Letters · 2009 · 128 citations · 25 references

DOI

Concepts

References

25

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

Andrew Hughes, S. E. Daniel, Linda Kilford et al. · Journal of Neurology Neurosurgery & Psychiatry · 1992 · 10.4K citations · Full text

, , +15

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Ranjita Betarbet, Todd Sherer, Gillian M. MacKenzie et al. · Nature Neuroscience · 2000 · 3.7K citations

, , +12

Mitochondrial Complex I Deficiency in Parkinson's Disease

Anthony H.V. Schapira, Jonathan M. Cooper, David T. Dexter et al. · Journal of Neurochemistry · 1990 · 2.3K citations

, , +13

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Christoph Richter, J W Park, B N Ames · Proceedings of the National Academy of Sciences · 1988 · 1.7K citations · Full text

, , +17

Mitochondrial Abnormalities in Alzheimer's Disease

Keisuke Hirai, Gjumrakch Aliev, Akihiko Nunomura et al. · Journal of Neuroscience · 2001 · 1.4K citations · Full text

, , +14