Intron Distribution in Ancient Paralogs Supports Random Insertion and Not Random Loss

Amino acid substitution matrices from protein blocks.

Steven Henikoff, Jorja G. Henikoff · Proceedings of the National Academy of Sciences · 1992 · 6.4K citations

Life Sciences, Bioinformatics, Evolutionary Biology +16

Why genes in pieces?

Walter Gilbert · Nature · 1978 · 2.3K citations · Full text

Life Sciences, Biology, Genetics +4

Evolutionary relationship of archaebacteria, eubacteria, and eukaryotes inferred from phylogenetic trees of duplicated genes.

Naoyuki Iwabe, K Kuma, M. Hasegawa et al. · Proceedings of the National Academy of Sciences · 1989 · 913 citations · Full text

Life Sciences, Biology, Evolutionary Biology +16

Evolution of the vacuolar H+-ATPase: implications for the origin of eukaryotes.

J. Peter Gogarten, Henrik Kibak, P. Dittrich et al. · Proceedings of the National Academy of Sciences · 1989 · 791 citations · Full text

Life Sciences, Biology, Microbiology +17

The Exon Theory of Genes

W Gilbert · Cold Spring Harbor Symposia on Quantitative Biology · 1987 · 396 citations

Life Sciences, Evolutionary Biology, Genetics +16