Concepedia

Combination Therapy With Fasudil and Sildenafil Ameliorates Monocrotaline-Induced Pulmonary Hypertension and Survival in Rats

Md. Elias-Al-Mamun, Kimio Satoh, Shinichi Tanaka, Tôru Shimizu, Suvd Nergui, Satoshi Miyata, Yoshihiro Fukumoto, Hiroaki Shimokawa

Circulation Journal · 2014 · 45 citations · 44 references

DOI Full text

Open access

Abstract

These results indicate that the combination therapy with fasudil and sildenafil shows the synergistic effects through the inhibition of Rho-kinase activity for the treatment of PH.

References

44

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Norbert F. Voelkel, Robert A. Quaife, Leslie A. Leinwand et al. · Circulation · 2006 · 1.2K citations

Heart Failure, Cardiovascular Disease, Cardiac Mechanic +5

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Mutsuki Amano, Kazuyasu Chihara, Kazushi Kimura et al. · Science · 1997 · 1.1K citations

Engineering, Cell Adhesion, Cytoskeleton +20

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

T. Ishizaki, Midori Maekawa, Katsuki Fujisawa et al. · The EMBO Journal · 1996 · 884 citations · Full text

Kda Ser/thr Protein, Signal Transduction, Molecular Physiology +12

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Pál Pacher, Takahiro Nagayama, Partha Mukhopadhyay et al. · Nature Protocols · 2008 · 713 citations · Full text

Cardiac Function, Health Sciences, Cardiac Physiology +10

Molecular pathogenesis of pulmonary arterial hypertension

Marlene Rabinovitch · Journal of Clinical Investigation · 2012 · 643 citations · Full text