Concepedia

Fyn Kinases Play a Critical Role in Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation or Amyloid‐β Peptide Treatment

Cai‐Ping Du, Ran Tan, Xiaoyu Hou

CNS Neuroscience & Therapeutics · 2012 · 36 citations · 20 references

DOIFull text

Open access

Abstract

Fyn mediates PSD-95Y523 phosphorylation, which may be responsible for the excitotoxic signal cascades and neuronal apoptosis in brain ischemia and Aβ neurotoxicity. Fyn is a potential therapeutic target for the treatment of ischemic stroke and AD.

References

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PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the <i>N</i> -methyl- <scp>d</scp> -aspartate receptor subunit NR2A

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