Chirality · 1991 · 69 citations · 22 references
Natural SciencesChemistryAnalytical ChemistryChromatographic AnalysisSpectroscopic AnalysisChiral ChromatographyChiral SeparationChromatographyCircular Dichroism SpectroscopyLiquid ChromatographyOptical SpectroscopyAnalytical Chiral ChromatographyChiral Analysis By SpectroscopyChirality DeterminationChromatographic Chiral SeparationCircular DichroismCircular Dichroism AnalysisCircular Dichroism Spectroscopy AnalysisElution Order
Abstract A circular dichroism‐based detection system presents several advantages in the HPLC analysis of chiral compounds because of the selective monitoring of optically active molecules. Its use allows reliable determination of enantiomeric excesses and elution order. To this end, the application of empirical, semiempirical, and nonempirical methods to get stereochemical information from the CD signal is reported. Furthermore, recording the CD spectra on line and evaluation of the dissymetry factor make the CD detection very powerful in characterizing the stereochemistry of chiral eluates.
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