Activation of transcription factors AP-1 and NF-κB in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation1

Abstract

Renal cortical AP-1 and NF-kappaB DNA binding were activated in chronic CsA nephrotoxicity. These activations were induced largely by means of RAS-independent mechanisms. It is suggested that prevention of CsA-induced DNA-binding activation of these transcription factors is at least in part responsible for the beneficial effects of Mg supplementation on CsA nephrotoxicity.