Blunted 5 -HT1A-receptor agonist-induced corticotropin and cortisol responses after long- term ipsapirone and fluoxetine administration to healthy subjects*

Abstract

Long-term administration of fluoxetine and ipsapirone did not influence resting plasma corticotropin and cortisol concentrations in the morning. Stimulation of corticotropin and cortisol release by a selective 5-HT1A-agonist is reduced with long-term administration of these serotoninergic antidepressants. This subsensitivity of postsynaptic 5-HT1A-receptors is reversible.