Synthesis of Substituted Barbituric Acids<i>via</i>Organozinc Reagents

Abstract

5-(1,2-Diarylethyl)- and 5-(1-aryl-3-butenyl)-barbituric acids are prepared in good yields from, 5-benzylidenebarbituric acids and benzylzinc bromide or allylzinc bromide, respectively. The products are used as starting materials for the synthesis of the correspondingly 5-substituted 1,3,5-triallyl-, 1,3,5-tris [2-propynyl]-, and 5-hydroxybarbituric acid derivatives.