Concepedia

Extracellular Nucleotides and Interleukin-8 Production by ARPE Cells: Potential Role of Danger Signals in Blood–Retinal Barrier Activation

Lia Judice Relvas, Christophe Bouffioux, Brice Marcet, Didier Communi, Maya Makhoul, Michael Horckmans, Daniel Bléro, Catherine Bruyns, Laure Caspers, Jean‐Marie Boeynaems,

Investigative Ophthalmology & Visual Science · 2009 · 26 citations · 20 references

DOI

Abstract

ATPgammaS, UTP, and UDP stimulate both basal and TNFalpha-induced IL-8 secretion in RPE cells through an ERK 1/2-dependent pathway. The results suggest that those effects are mediated by P2Y(2) and P2Y(6) receptors.

References

20

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

Marco Prinz · Journal of Clinical Investigation · 2006 · 385 citations · Full text

A filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents

Laurie S. Minamide, James R. Bamburg · Analytical Biochemistry · 1990 · 267 citations

, , +10

Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells

Matam Vijay Kumar, Chandrasekharam N. Nagineni, Marian S. Chin et al. · Journal of Neuroimmunology · 2004 · 241 citations · Full text

P2Y6 Nucleotide Receptor Mediates Monocyte Interleukin-8 Production in Response to UDP or Lipopolysaccharide

Michel Warny, Samer Aboudola, Simon C. Robson et al. · Journal of Biological Chemistry · 2001 · 153 citations · Full text

Polarized secretion of IL-6 and IL-8 by human retinal pigment epithelial cells

Gertjan M. Holtkamp, Michel van Rossem, Alex F. de Vos et al. · Clinical & Experimental Immunology · 1998 · 144 citations · Full text

, , +17