Concepedia

The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol

Chris Downing, Michael J. Marks, Colin Larson, Thomas E. Johnson

Pharmacogenetics and Genomics · 2010 · 10 citations · 49 references

DOI

Abstract

Altogether, this data provides convincing evidence that mGluR5 mediates differential sensitivity to the sedative effects of ethanol. Studies from the human literature have also identified mGluR5 as a potential candidate gene for ethanol sensitivity.

References

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András Nagy, Janet Rossant, Roland Nagy et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations · Full text

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Marc A. Schuckit · American Journal of Psychiatry · 1994 · 845 citations

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

Youming Lu, Zhengping Jia, Christopher Janus et al. · Journal of Neuroscience · 1997 · 630 citations · Full text

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice

Binnaz Yalcin, Saffron A.G. Willis‐Owen, Janice M. Fullerton et al. · Nature Genetics · 2004 · 284 citations · Full text

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