Concepedia

Inhibition of Bone Resorption in Vitro by a Cartilage-Derived Anticollagenase Factor

John E. Horton, Frederick H. Wezeman, Klaus E. Kuettner

Science · 1978 · 66 citations · 15 references

DOI

Abstract

A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.

References

15

Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

John E. Horton, Lawrence G. Raisz, Hollis A. Simmons et al. · Science · 1972 · 563 citations

, , +18

Effect of Phosphate, Calcium and Magnesium on Bone Resorption and Hormonal Responses in Tissue Culture

Lawrence G. Raisz · Endocrinology · 1969 · 412 citations

, , +24

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

Derrick R. Robinson, A H Tashjian, Lawrence Levine · Journal of Clinical Investigation · 1975 · 387 citations · Full text

, , +13

The resistance of certain tissues to invasion. III. Cartilage extracts inhibit the growth of fibroblasts and endothelial cells in culture.

Reuben Eisenstein, Klaus E. Kuettner, C. Neapolitan et al. · PubMed · 1975 · 157 citations · Full text

Tumor Cell Collagenase and Its Inhibition by a Cartilage-Derived Protease Inhibitor

Klaus E. Kuettner, L. W. Soble, Richard L. Croxen et al. · Science · 1977 · 143 citations

, , +16