Indium(III) Chloride Mediated Michael Addition of Indoles to Ketene S,S-Acetals: Synthesis of Bis- and Tris-indolylketones

Abstract

A series of bis and tris-indolylketones and meridianin alkaloids are prepared by one pot Michael reaction of indole and ketene S,S-acetals under solvent-free condition using mild Lewis acid <TEX>$InCl_3$</TEX>.