Case Reports in Psychiatry · 2013 · 21 citations · 9 references
MedicinePharmacotherapyPsychiatryKidney TransplantationNeuropsychiatryPsychopharmacologyAntipsychotic PharmacologyAntipsychotic PharmacotherapyAntipsychotic TherapyImmunosuppression In Kidney TransplantationPsychotic DisordersTreatment Of Mental DisordersAntipsychotic Medication ManagementAssociated Neurological SymptomsDrug-induced ManiaKidney Transplant CareKidney Transplant ImmunosuppressionMedication-induced PsychosisTacrolimus TherapyTransplant Psychiatry
Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.
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