Chemistry - A European Journal · 2000 · 101 citations · 0 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganometallic ChemistryHeterocycle SynthesisMetal Catalysis1, 2-Addition1, 4-AdditionCopper-catalyzed CouplingGrignard Reagent SynthesisHalogen Exchange ReactionsMagnesium CatalysisMagnesium ExchangeSolid-solid Phase Transformations
The iodine-magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper-catalyzed reactions such as allylation or 1,4-addition. Using this halogen-metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.