12-O-Tetradecanoylphorbol-13-acetate Promotes Breast Cancer Cell Motility by Increasing S100A14 Level in a Kruppel-like Transcription Factor 4 (KLF4)-dependent Manner

Abstract

The transcriptional regulation of S100A14 and its underlying mechanism have not been fully elucidated. Results: The activation of S100A14 promoter by KLF4 mediates its up-regulation upon TPA stimulation. Conclusion: S100A14 partly mediates TPA-induced cell motility in a KLF4-dependent manner. Significance: KLF4 plays a significant and previously unrecognized role in regulation of S100A14.