Antimicrobial Agents and Chemotherapy · 1983 · 32 citations · 0 references
MedicinePharmacologyPharmacotherapyAntimicrobial PharmacologyAntimicrobial PharmacotherapyCervical DiseaseAntibiotic ProphylaxisCervical InfectionSexually Transmitted Infection CareSexually Transmitted Infection PharmacotherapySexually Transmitted InfectionsAntibiotic Therapy For GonorrheaCeftriaxone TherapyMinimal Effective Concentration
Uncomplicated gonorrhea of 122 mucosal sites in 51 women was successfully treated with either a single intramuscular dose of 250 mg of ceftriaxone (23 patients) or two intramuscular doses of 4.8 X 10(6) U of aqueous procaine penicillin G (28 patients). Women treated with ceftriaxone had 22 cervical, 12 urethral, 10 anal canal, and 5 pharyngeal infections. All 122 pretreatment isolates were inhibited by 0.0125 microgram or less of ceftriaxone per ml. The minimal concentration needed to inhibit 90% of isolates was 0.006 microgram/ml for ceftriaxone and 0.2 microgram/ml for penicillin G. Ceftriaxone was very well tolerated and caused no toxicity.