Concepedia

Sirolimus for the treatment of complicated vascular anomalies in children

Adrienne M. Hammill, MarySue Wentzel, Anita Gupta, Stephen C. Nelson, Anne W. Lucky, Ravi Elluru, Roshni Dasgupta, Richard G. Azizkhan, Denise M. Adams

Pediatric Blood & Cancer · 2011 · 600 citations · 31 references

DOIFull text

Open access

Abstract

Sirolimus appears to be effective and safe in patients with life-threatening vascular anomalies and represents an important tool in treating these diseases. These findings are currently being further evaluated in a Phase II safety and efficacy trial.

References

31

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

John J. Bissler, Francis X. McCormack, Lisa R. Young et al. · New England Journal of Medicine · 2008 · 1.3K citations · Full text

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

Taija Mäkinen · The EMBO Journal · 2001 · 839 citations · Full text

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Thrombocytopenic Coagulopathy (Kasabach-Merritt Phenomenon) Is Associated with Kaposiform Hemangioendothelioma and Not with Common Infantile Hemangioma

Molly Sarkar, John B. Mulliken, Harry P. Kozakewich et al. · Plastic & Reconstructive Surgery · 1997 · 448 citations

Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy

Charles F. Barlow, Cedric J. Priebe, John B. Mulliken et al. · The Journal of Pediatrics · 1998 · 444 citations

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Kaposiform Hemangioendothelioma

Lisa L Lyons, Paula E. North, Fernand Mac–Moune Lai et al. · The American Journal of Surgical Pathology · 2004 · 375 citations

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