The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

Somatic Variant, Braf Gene, Genetics +5

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Gregory J. Hannon, David Beach · Nature · 1994 · 1.9K citations

Developmental Biology, Signal Transduction, Cell Division +7

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

Inga Reynisdóttir, Kornélia Polyák, Antonio Iavarone et al. · Genes & Development · 1995 · 963 citations · Full text

Cytokine, Signal Transduction, G1 Progression +15

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

Michael Datto, Y Li, Joanne Fanelli Panus et al. · Proceedings of the National Academy of Sciences · 1995 · 938 citations · Full text

Cell Proliferation, Cell Cycle, Tumor Biology +20

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Sizhi Paul Gao, Kevin G. Mark, Kenneth Leslie et al. · Journal of Clinical Investigation · 2007 · 656 citations · Full text

Human Lung Adenocarcinomas, Oncology, Cell Regulation +15