Palladium-Catalyzed Olefination and Arylation of 2-Substituted 1,2,3-Triazole <i>N</i>-Oxides

Abstract

Two highly efficient protocols for the regioselective synthesis of 2-substituted 4-alkenyl- and 4-aryl-1,2,3-triazoles by the palladium-catalyzed C-H functionalization of 1,2,3-triazole N-oxides are reported. A possible pathway of direct alkenylation with 1-octene and vinyl acetate is discussed.