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IMPROVED METHOD FOR DEMETHYLATION OF NITRO- CATECHOL METHYL ETHERS
19
Citations
6
References
2002
Year
Derivative (Chemistry)EngineeringExcellent YieldCorresponding Methyl EthersOrganic ChemistryCatalysisChemistryPharmacologyChemical DerivativeSynthetic ChemistryAluminium ChlorideCatalytic SynthesisNatural Product Synthesis
ABSTRACT Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate.
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