Journal of the Brazilian Chemical Society · 2011 · 27 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyChemotherapyDrug DiscoveryStructure-activity RelationshipsAntiparasitic AgentsAntiparasitic ChemotherapyAntiparasitic PharmacologyLead Compound DesignStructure-activity Relationship AnalysisAntileishmanial ChemotherapyAntileishmanial TreatmentAntimalarial ChemotherapyAntimalarial Drug DevelopmentMedicinal Chemistry ApplicationsStructure - Activity Relationship OptimizationSynthetic Antiparasitic CompoundsTreatment Of Leishmaniasis
Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4-carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.