Concepedia

Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib

Paul W. Manley, Nikolaus Stiefl, Sandra W. Cowan‐Jacob, Susan Kaufman, Jürgen Mestan, Markus Wartmann, Marion Wiesmann, Richard Woodman, Neil J. Gallagher

Bioorganic & Medicinal Chemistry · 2010 · 150 citations · 53 references

Open access

Concepts

MedicineMedicinal ChemistryPharmacologyMolecular PharmacologyPharmacodynamicsStructure-activity RelationshipsStructure-activity Relationship AnalysisImidazole ChemistryMolecular Descriptors For Drug-likenessPharmacological ClassificationPharmacological SpecificityPrimary Resistance To Imatinib

References

53

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

Pharmacy, Chemistry, Pharmacology +15

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

CB Lozzio, BB Lozzio · Blood · 1975 · 2.8K citations

Medicine, Hematology, Oncology +14

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

CB Lozzio, BB Lozzio · Blood · 1975 · 2.3K citations · Full text

Medicine, Hematology, Oncology +14

Chemical Similarity Searching

Peter Willett, John M. Barnard, Geoffrey M. Downs · Journal of Chemical Information and Computer Sciences · 1998 · 1.8K citations

Pharmacy, Chemistry, Drug Discovery +13

Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia

Giuseppe Saglio, Dong‐Wook Kim, Surapol Issaragrisil et al. · New England Journal of Medicine · 2010 · 1.7K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +10