Growth hormone- and pressure overload-induced cardiac hypertrophy evoke different responses to ischemia-reperfusion and mechanical stretch

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

Q Li, B Li, Xiaohui Wang et al. · Journal of Clinical Investigation · 1997 · 500 citations · Full text

Medicine, Cardiology, Pathobiology +16

Akt induces enhanced myocardial contractility and cell size <i>in vivo</i> in transgenic mice

Gianluigi Condorelli, Alessandra Drusco, Giorgio Stassi et al. · Proceedings of the National Academy of Sciences · 2002 · 460 citations

Life Sciences, Cardiology, Physiology +14

The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway

Julie R. McMullen, Tetsuo Shioi, Weei-Yuarn Huang et al. · Journal of Biological Chemistry · 2004 · 400 citations · Full text

Life Sciences, Molecular Biology, Physiology +14

Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress

Giovanni Esposito, Antonio Rapacciuolo, Sathyamangla V. Naga Prasad et al. · Circulation · 2002 · 379 citations

Life Sciences, Cardiology, Physiology +13

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

Arthur M. Feldman, Ellen O. Weinberg, Phillip E. Ray et al. · Circulation Research · 1993 · 355 citations · Full text

Life Sciences, Molecular Biology, Physiology +13